Products
HMGCR antibody
- SPECIFICATIONS
- CITATIONS
- Product Name
- HMGCR antibody
- Catalogue No.
- FNab03929
- Size
- 100μg
- Form
- liquid
- Purification
- Immunogen affinity purified
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- polyclonal
- Isotype
- IgG
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months (Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
- Alternative Names
- HMG CoA reductase antibody, HMGCR antibody, 3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody, HMDH antibody
- UniProt ID
- P04035
- Observed MW
- 100 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF
- Recommended dilution
- WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab03929(HMGCR antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human breast cancer using FNab03929(HMGCR antibody) at dilution of 1:100
- Background
- HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
IF: 3.2
- Journal:
- Immunity, Inflammation and Disease
- Author:
- Department of Infectious Disease, The Affiliated People's Hospital of Ningbo University, Ningbo City, Zhejiang Province, China
- Cited Date:
- 2023-08-25
- Product: